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1,1'-Azobis(formamide)

Catalog No: 20563
CAS Number: 123-77-3
Purity: 98% Min.

1,1'-Azobis(formamide) has been shown to have the ability to induce asthma and skin sensation in humans.

For research use only. We do not sell to patients.

Chemical Information

Name1,1'-Azobis(formamide)
Iupac Chemical Name1,2-Diazenedicarboxamide
Synonyms1,1'-Azobis(formamide)
Molecular FormulaC2H4N4O2
Molecular Weight116.08
SmileO=C(/N=N/C(N)=O)N
InChiKeyXOZUGNYVDXMRKW-AATRIKPKSA-N
InChiInChI=1S/C2H4N4O2/c3-1(7)5-6-2(4)8/h(H2,3,7)(H2,4,8)/b6-5+
CAS Number123-77-3
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Ordering Information

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FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Wang X, Zhao C, Huang W, Wang Q, Liu C, Yang G. Near-infrared hyperspectral imaging for detection and quantification of1: Wang X, Zhao C, Huang W, Wang Q, Liu C, Yang G. Near-infrared hyperspectral imaging for detection and quantification of azodicarbonamide in flour. J Sci Food Agric. 2018 May;98(7):2793-2800. doi: 10.1002/jsfa.8776. Epub 2017 Nov 28. PubMed PMID: 29124771.

2: Che W, Sun L, Zhang Q, Zhang D, Ye D, Tan W, Wang L, Dai C. Application of Visible/Near-Infrared Spectroscopy in the Prediction of Azodicarbonamide in Wheat Flour. J Food Sci. 2017 Oct;82(10):2516-2525. doi: 10.1111/1750-3841.13859. Epub 2017 Sep 11. PubMed PMID: 28892170.

3: Arts J, Kimber I. Azodicarbonamide (ADCA): A reconsideration of classification as a respiratory sensitiser. Regul Toxicol Pharmacol. 2017 Oct;89:268-278. doi: 10.1016/j.yrtph.2017.07.018. Epub 2017 Jul 20. PubMed PMID: 28734852.

4: Kalo D, Kant S, Srivastava K, Sharma AK. Assess drug resistance pattern and genetic profile of Mycobacterium tuberculosis clinical isolates by molecular typing methods using direct repeats and IS6110 in pulmonary tuberculosis cases. Lung India. 2017 Mar-Apr;34(2):155-159. doi: 10.4103/0970-2113.201314. PubMed PMID: 28360464; PubMed Central PMCID: PMC5351358.

5: Yasui A, Oishi M, Hayafuji C, Kobayashi C, Shindo T, Ozawa H, Nakazato M. Analysis of Azodicarbonamide in Wheat Flour and Prepared Flour Mixes. Shokuhin Eiseigaku Zasshi. 2016;57(5):133-138. Japanese. PubMed PMID: 27784863.

6: Azadbakht A, Roushani M, Abbasi AR, Derikvand Z, Menati S. Bifunctional impedimetric sensors based on azodicarboxamide supported on modified graphene nanosheets. Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:221-30. doi: 10.1016/j.msec.2016.05.023. Epub 2016 May 8. PubMed PMID: 27612707.

7: Wang Y, Chan W. Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography-Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples. J Agric Food Chem. 2016 Apr 6;64(13):2802-8. doi: 10.1021/acs.jafc.6b00651. Epub 2016 Mar 24. PubMed PMID: 26985968.

8: Srivastava R, Batra A, Tyagi A, Dhawan D, Ramakrishnan L, Bakhshi S. Adiponectin correlates with obesity: A study of 159 childhood acute leukemia survivors from India. Indian J Cancer. 2015 Apr-Jun;52(2):195-7. doi: 10.4103/0019-509X.175824. PubMed PMID: 26853401.

9: Krull SM, Susarla R, Afolabi A, Li M, Ying Y, Iqbal Z, Bilgili E, Davé RN. Polymer strip films as a robust, surfactant-free platform for delivery of BCS Class II drug nanoparticles. Int J Pharm. 2015 Jul 15;489(1-2):45-57. doi: 10.1016/j.ijpharm.2015.04.034. Epub 2015 Apr 15. PubMed PMID: 25888803.

10: Tian WR, Sang YX, Wang XH. Semicarbazide - from state-of-the-art analytical methods and exposure to toxicity: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(11):1850-60. doi: 10.1080/19440049.2014.953012. Epub 2014 Oct 28. Review. PubMed PMID: 25127068.

11: Bhakay A, Azad M, Bilgili E, Dave R. Redispersible fast dissolving nanocomposite microparticles of poorly water-soluble drugs. Int J Pharm. 2014 Jan 30;461(1-2):367-79. doi: 10.1016/j.ijpharm.2013.11.059. Epub 2013 Dec 11. PubMed PMID: 24333905.

12: Choudhury AD, Choudhury MD, Chetia P, Chowdhury A, Talukdar AD. An in silico appraisal of azoic and disulphide derivatives for anticancer activity against HPV E6 oncoprotein to medicate cervical cancer. Comb Chem High Throughput Screen. 2014 Jan;17(1):38-46. PubMed PMID: 24164050.

13: Xie Y, Li P, Zhang J, Wang H, Qian H, Yao W. Comparative studies by IR, Raman, and surface-enhanced Raman spectroscopy of azodicarbonamide, biurea and semicarbazide hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct;114:80-4. doi: 10.1016/j.saa.2013.05.055. Epub 2013 May 25. PubMed PMID: 23751223.

14: Ye J, Wang XH, Sang YX, Liu Q. Assessment of the determination of azodicarbonamide and its decomposition product semicarbazide: investigation of variation in flour and flour products. J Agric Food Chem. 2011 Sep 14;59(17):9313-8. doi: 10.1021/jf201819x. Epub 2011 Aug 5. PubMed PMID: 21786817.

15: Zehbe I, Richard C, Lee KF, Campbell M, Hampson L, Hampson IN. Lopinavir shows greater specificity than zinc finger ejecting compounds as a potential treatment for human papillomavirus-related lesions. Antiviral Res. 2011 Aug;91(2):161-6. doi: 10.1016/j.antiviral.2011.05.016. Epub 2011 Jun 2. PubMed PMID: 21669231.

16: Alasino MC, Osella CA, De La Torre MA, Sanchez HD. Use of sodium stearoyl lactylate and azodicarbonamide in wheat flour breads with added pea flour. Int J Food Sci Nutr. 2011 Jun;62(4):385-91. doi: 10.3109/09637486.2010.538671. Epub 2011 Feb 9. PubMed PMID: 21306191.

17: Yoon H, Kim GH, Koh YH. A micro-scale surface-structured PCL scaffold fabricated by a 3D plotter and a chemical blowing agent. J Biomater Sci Polym Ed. 2010;21(2):159-70. doi: 10.1163/156856209X410292. PubMed PMID: 20092682.

18: García CC, Ellenberg PC, Artuso MC, Scolaro LA, Damonte EB. Characterization of Junín virus particles inactivated by a zinc finger-reactive compound. Virus Res. 2009 Jul;143(1):106-13. doi: 10.1016/j.virusres.2009.03.010. Epub 2009 Apr 1. PubMed PMID: 19463727.

19: Zawadzki M, Maksymowicz K. [Suspected azodicarbonamide poisoning in a patient with acute hemorrhaging pancreatitis]. Arch Med Sadowej Kryminol. 2007 Oct-Dec;57(4):430-2. Review. Polish. PubMed PMID: 18432145.

20: Noonan GO, Begley TH, Diachenko GW. Semicarbazide formation in flour and bread. J Agric Food Chem. 2008 Mar 26;56(6):2064-7. doi: 10.1021/jf073198g. Epub 2008 Feb 27. PubMed PMID: 18303820. azodicarbonamide in flour. J Sci Food Agric. 2018 May;98(7):2793-2800. doi: 10.1002/jsfa.8776. Epub 2017 Nov 28. PubMed PMID: 29124771.


2: Che W, Sun L, Zhang Q, Zhang D, Ye D, Tan W, Wang L, Dai C. Application of Visible/Near-Infrared Spectroscopy in the Prediction of Azodicarbonamide in Wheat Flour. J Food Sci. 2017 Oct;82(10):2516-2525. doi: 10.1111/1750-3841.13859. Epub 2017 Sep 11. PubMed PMID: 28892170.

3: Arts J, Kimber I. Azodicarbonamide (ADCA): A reconsideration of classification as a respiratory sensitiser. Regul Toxicol Pharmacol. 2017 Oct;89:268-278. doi: 10.1016/j.yrtph.2017.07.018. Epub 2017 Jul 20. PubMed PMID: 28734852.

4: Kalo D, Kant S, Srivastava K, Sharma AK. Assess drug resistance pattern and genetic profile of Mycobacterium tuberculosis clinical isolates by molecular typing methods using direct repeats and IS6110 in pulmonary tuberculosis cases. Lung India. 2017 Mar-Apr;34(2):155-159. doi: 10.4103/0970-2113.201314. PubMed PMID: 28360464; PubMed Central PMCID: PMC5351358.

5: Yasui A, Oishi M, Hayafuji C, Kobayashi C, Shindo T, Ozawa H, Nakazato M. Analysis of Azodicarbonamide in Wheat Flour and Prepared Flour Mixes. Shokuhin Eiseigaku Zasshi. 2016;57(5):133-138. Japanese. PubMed PMID: 27784863.

6: Azadbakht A, Roushani M, Abbasi AR, Derikvand Z, Menati S. Bifunctional impedimetric sensors based on azodicarboxamide supported on modified graphene nanosheets. Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:221-30. doi: 10.1016/j.msec.2016.05.023. Epub 2016 May 8. PubMed PMID: 27612707.

7: Wang Y, Chan W. Automated In-Injector Derivatization Combined with High-Performance Liquid Chromatography-Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples. J Agric Food Chem. 2016 Apr 6;64(13):2802-8. doi: 10.1021/acs.jafc.6b00651. Epub 2016 Mar 24. PubMed PMID: 26985968.

8: Srivastava R, Batra A, Tyagi A, Dhawan D, Ramakrishnan L, Bakhshi S. Adiponectin correlates with obesity: A study of 159 childhood acute leukemia survivors from India. Indian J Cancer. 2015 Apr-Jun;52(2):195-7. doi: 10.4103/0019-509X.175824. PubMed PMID: 26853401.

9: Krull SM, Susarla R, Afolabi A, Li M, Ying Y, Iqbal Z, Bilgili E, Davé RN. Polymer strip films as a robust, surfactant-free platform for delivery of BCS Class II drug nanoparticles. Int J Pharm. 2015 Jul 15;489(1-2):45-57. doi: 10.1016/j.ijpharm.2015.04.034. Epub 2015 Apr 15. PubMed PMID: 25888803.

10: Tian WR, Sang YX, Wang XH. Semicarbazide - from state-of-the-art analytical methods and exposure to toxicity: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(11):1850-60. doi: 10.1080/19440049.2014.953012. Epub 2014 Oct 28. Review. PubMed PMID: 25127068.

11: Bhakay A, Azad M, Bilgili E, Dave R. Redispersible fast dissolving nanocomposite microparticles of poorly water-soluble drugs. Int J Pharm. 2014 Jan 30;461(1-2):367-79. doi: 10.1016/j.ijpharm.2013.11.059. Epub 2013 Dec 11. PubMed PMID: 24333905.

12: Choudhury AD, Choudhury MD, Chetia P, Chowdhury A, Talukdar AD. An in silico appraisal of azoic and disulphide derivatives for anticancer activity against HPV E6 oncoprotein to medicate cervical cancer. Comb Chem High Throughput Screen. 2014 Jan;17(1):38-46. PubMed PMID: 24164050.

13: Xie Y, Li P, Zhang J, Wang H, Qian H, Yao W. Comparative studies by IR, Raman, and surface-enhanced Raman spectroscopy of azodicarbonamide, biurea and semicarbazide hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct;114:80-4. doi: 10.1016/j.saa.2013.05.055. Epub 2013 May 25. PubMed PMID: 23751223.

14: Ye J, Wang XH, Sang YX, Liu Q. Assessment of the determination of azodicarbonamide and its decomposition product semicarbazide: investigation of variation in flour and flour products. J Agric Food Chem. 2011 Sep 14;59(17):9313-8. doi: 10.1021/jf201819x. Epub 2011 Aug 5. PubMed PMID: 21786817.

15: Zehbe I, Richard C, Lee KF, Campbell M, Hampson L, Hampson IN. Lopinavir shows greater specificity than zinc finger ejecting compounds as a potential treatment for human papillomavirus-related lesions. Antiviral Res. 2011 Aug;91(2):161-6. doi: 10.1016/j.antiviral.2011.05.016. Epub 2011 Jun 2. PubMed PMID: 21669231.

16: Alasino MC, Osella CA, De La Torre MA, Sanchez HD. Use of sodium stearoyl lactylate and azodicarbonamide in wheat flour breads with added pea flour. Int J Food Sci Nutr. 2011 Jun;62(4):385-91. doi: 10.3109/09637486.2010.538671. Epub 2011 Feb 9. PubMed PMID: 21306191.

17: Yoon H, Kim GH, Koh YH. A micro-scale surface-structured PCL scaffold fabricated by a 3D plotter and a chemical blowing agent. J Biomater Sci Polym Ed. 2010;21(2):159-70. doi: 10.1163/156856209X410292. PubMed PMID: 20092682.

18: García CC, Ellenberg PC, Artuso MC, Scolaro LA, Damonte EB. Characterization of Junín virus particles inactivated by a zinc finger-reactive compound. Virus Res. 2009 Jul;143(1):106-13. doi: 10.1016/j.virusres.2009.03.010. Epub 2009 Apr 1. PubMed PMID: 19463727.

19: Zawadzki M, Maksymowicz K. [Suspected azodicarbonamide poisoning in a patient with acute hemorrhaging pancreatitis]. Arch Med Sadowej Kryminol. 2007 Oct-Dec;57(4):430-2. Review. Polish. PubMed PMID: 18432145.

20: Noonan GO, Begley TH, Diachenko GW. Semicarbazide formation in flour and bread. J Agric Food Chem. 2008 Mar 26;56(6):2064-7. doi: 10.1021/jf073198g. Epub 2008 Feb 27. PubMed PMID: 18303820.

Chemical Structure

20563 - 1,1'-Azobis(formamide) | CAS 123-77-3

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