ABT888
Catalog No: 17022801
CAS Number: 912445-05-7
Purity: 98%
Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.
ABT-888 is a potent inhibitor of both PARP-1 and PARP-2 with K(i)s of 5.2 and 2.9 nmol/L, respectively. The compound has good oral bioavailability and crosses the blood-brain barrier [1]. ABT-888 displayed excellent potency against both the PARP-1 and PARP-2 enzymes with a K(i) of 5 nM and in a C41 whole cell assay with an EC(50) of 2 nM [2]. ABT-888 reduced clonogenic survival in H460 lung cancer cells, and inhibited DNA repair as shown by enhanced expression of DNA strand break marker histone gamma-H2AX.
For research use only. We do not sell to patients.
Chemical Information
| Name | ABT888 |
|---|---|
| Iupac Chemical Name | ABT888 |
| Synonyms | ABT-888 dihydrochloride; ABT888 dihydrochloride; ABT 888 dihydrochloride |
| Molecular Formula | C₁₃H₁₈Cl₂N₄O |
| Molecular Weight | 317.21 |
| Smile | C[C@@H]1CCNC1c2[nH]c3cccc(c3n2)C(=O)N |
| InChiKey | FXRVOXLVQCUUGN-PVSHWOEXSA-N |
| InChi | InChI=1S/C13H16N4O/c1-7-5-6-15-10(7)13-16-9-4-2-3-8(12(14)18)11(9)17-13/h2-4,7,10,15H,5-6H2,1H3,(H2,14,18)(H,16,17)/t7-,10?/m1/s1 |
| CAS Number | 912445-05-7 |
| MDL | MFCD12031514 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
