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AMG-337 Catalog No : 01181

Chemical Information

Product NameAMG-337
Iupac Chemical Name6-[(1R)-1-[8-fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-5-methylidene-1,6-naphthyridine 
SynonymsAMG337; AMG 337 
Molecular FormulaC23H22FN7O3 
Molecular Weight463.464 
SmileCC(C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=NC=C(C=C5C4=C)OCCOC
InChiKeyWKIALOXOAZXGMG-UHFFFAOYSA-N
InChiInChI=1S/C24H24FN7O2/c1-15-20-10-19(34-8-7-33-4)12-26-22(20)5-6-31(15)16(2)23-28-29-24-21(25)9-17(14-32(23)24)18-11-27-30(3)13-18/h5-6,9-14,16H,1,7-8H2,2-4H3
Cas1173699-31-4

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

AMG-337 is a potent and highly selective small molecule ATP-competitive MET kinase inhibitor. AMG 337 inhibits MET kinase activity with an IC50 of < 5nM in enzymatic assays. 

Chemical Structure

01181 - AMG-337 | CAS 1173699-31-4

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