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AZ3146 Catalog No : 51903

Chemical Information

Product NameAZ3146
Iupac Chemical Name9-cyclopentyl-2-(2-methoxy-4-(1-methylpiperidin-4-yloxy)phenylamino)-7-methyl-7H-purin-8(9H)-one 
SynonymsAZ3146;AZ-3146 
Molecular FormulaC24H32N6O3 
Molecular Weight452.55 
SmileC1(CCCC1)N1C2=NC(=NC=C2N(C1=O)C)NC1=C(C=C(C=C1)OC1CCN(CC1)C)OC
InChiKeyYUKWVHPTFRQHMF-UHFFFAOYSA-N
InChiInChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)
Cas1124329-14-1

Technical Data

Appearanceoff-white solid 
Purity98% 
Solubility5mg/ml in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature. 
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Description

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit. 

Chemical Structure

51903 - AZ3146 | CAS 1124329-14-1

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