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AZD-1480 Catalog No : 010816

Chemical Information

Product NameAZD-1480
Iupac Chemical Name5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine 
SynonymsAZD1480; AZD 1480 
Molecular FormulaC14H14ClFN8 
Molecular Weight348.766 
SmileCC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F
InChiKeyPDOQBOJDRPLBQU-UHFFFAOYSA-N
InChiInChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)
Cas935666-88-9

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Quality control

Description

AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. 

Chemical Structure

010816 - AZD-1480 | CAS 935666-88-9

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