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AZD-5904 Catalog No : 181121

Chemical Information

Product NameAZD-5904
Iupac Chemical Name(S)-3-((tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
SynonymsAZ1, AZ 1 AZ-1; TX4; TX-4; TX 4; AZD-5904; AZD 5904; AZD5904.
Molecular FormulaC10H12N4O2S
Molecular Weight252.292
SmileO=C1NC(N(C[C@H]2OCCC2)C3=C1NC=N3)=S
InChiKeyRSPDBEVKURKEII-LURJTMIESA-N
InChiInChI=1S/C10H12N4O2S/c15-9-7-8(12-5-11-7)14(10(17)13-9)4-6-2-1-3-16-6/h5-6H,1-4H2,(H,11,12)(H,13,15,17)/t6-/m0/s1
Cas618913-30-7

Technical Data

Appearanceoff-white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

AZD5904 is a potent orally bioavailable MPO inhibitor. In preclinical studies, AZD5904 inhibited the isolated MPO enzyme with an IC50 of 140 nM and was approximately equipotent in assays of rat and mouse MPO enzyme activity.

Chemical Structure

181121 - AZD-5904  | CAS 618913-30-7

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