+0086-27-59253327 sales@sun-shinechem.com

AZD-8835 Catalog No : 102703

Chemical Information

Product NameAZD-8835
Iupac Chemical Name1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one 
SynonymsAZD 8835;AZD8835 
Molecular FormulaC22H31N9O3 
Molecular Weight469.55 
SmileO=C(N1CCC(C2=NN(CC)C(C3=NC(C4=NN=C(C(C)(C)C)O4)=C(N)N=C3)=N2)CC1)CCO
InChiKeyZGRDYKFVDCFJCZ-UHFFFAOYSA-N
InChiInChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24)
Cas1620576-64-8

Technical Data

Appearanceoff-white to light yellow solid 
Purity98% by HPLC at 215nm 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature 
Quality control HNMR HPLC

Description

AZD8835 is a selective, oral inhibitor of PI3K isoforms  and  with the following activity in enzymatic assays: PI3K C IC50 = 6nM (equipotent vs wt and E545K / H1047R mutants); PI3K C IC50 = 6nM; PI3K  C IC50 = 90nM; PI3K  C IC50 = 431nM. Inhibition of signalling  in cells (pAKT endpoint): PI3K C IC50= 57nM; PI3K C IC50= 49nM; PI3K C IC50= 3.6M; PI3K -  IC50= 532nM 

Chemical Structure

102703 - AZD-8835 | CAS 1620576-64-8

Package

SizePrice

Quick Order

Change

Contact Us