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AZD1208 Catalog No : 51702

Chemical Information

Product NameAZD1208
Iupac Chemical Name(5Z)-5-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione 
Molecular FormulaC21H21N3O2S 
Molecular Weight379.48 

Technical Data

Appearancelight-yellow solid to off-white solid 
Purity98% by HPLC/HNMR 
Solubility2mg/ml in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature. 
Quality control HNMR HPLC


AZD1208 is a potent, highly selective, and orally available Pim kinase inhibitor that effectively inhibits all three isoforms at <5 nM or <150 nM in enzyme and cell assays, respectively. AZD1208 inhibited the growth of 5 of 14 acute myeloid leukemia (AML) cell lines tested, and sensitivity correlates with Pim-1 expression and STAT5 activation. AZD1208 causes cell cycle arrest and apoptosis in MOLM-16 cells, accompanied by a dose-dependent reduction in phosphorylation of Bcl-2 antagonist of cell death, 4EBP1, p70S6K, and S6, as well as increases in cleaved caspase 3 and p27. Inhibition of p4EBP1 and p-p70S6K and suppression of translation are the most representative effects of Pim inhibition in sensitive AML cell lines. AZD1208 inhibits the growth of MOLM-16 and KG-1a xenograft tumors in vivo with a clear pharmacodynamic-pharmacokinetic relationship. AZD1208 also potently inhibits colony growth and Pim signaling substrates in primary AML cells from bone marrow that are Flt3 wild-type or Flt3 internal tandem duplication mutant.


Chemical Structure

51702 - AZD1208 | CAS 1204144-28-4


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