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AZD8186 Catalog No : 122925

Chemical Information

Product NameAZD8186
Iupac Chemical Name8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide 
SynonymsAZD-8186 
Molecular FormulaC24H25F2N3O4 
Molecular Weight457.470 
SmileCC(C1=C2C(=CC(=C1)C(=O)N(C)C)C(=O)C=C(O2)N3CCOCC3)NC4=CC(=CC(=C4)F)F
InChiKeyLMJFJIDLEAWOQJ-UHFFFAOYSA-N
InChiInChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3
Cas1627494-13-6

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3K (IC50=4 nM) and PI3K (IC50=12 nM) with selectivity over PI3K (IC50=35 nM) and PI3K (IC50=675 nM). 

Chemical Structure

122925 - AZD8186 | CAS 1627494-13-6

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