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AZD9291 Catalog No : 52306

Chemical Information

Product NameAZD9291
Iupac Chemical Name2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]- 
SynonymsAZD9291;AZD 9291;AZD-9291;Mereletinib. 
Molecular FormulaC28H33N7O2 
Molecular Weight499.61 
SmileCN(CCN(C1=C(C=C(C(=C1)OC)NC1=NC=CC(=N1)C1=CN(C2=CC=CC=C12)C)NC(C=C)=O)C)C
InChiKeyDUYJMQONPNNFPI-UHFFFAOYSA-N
InChiInChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
Cas1421373-65-0

Technical Data

AppearanceWhite solid powder 
Purity99.0% 
SolubilitySoluble in DMSO to 20 mM 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

AZD9291 is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR, respectively. Phase 3. 

Chemical Structure

52306 - AZD9291 | CAS 1421373-65-0

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