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Afuresertib Catalog No : 011811

Chemical Information

Product NameAfuresertib
Iupac Chemical NameN-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide 
SynonymsGSK2110183C 
Molecular FormulaC18H17Cl2FN4OS 
Molecular Weight427.323 
SmileCN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl
InChiKeyAFJRDFWMXUECEW-UHFFFAOYSA-N
InChiInChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)
Cas1047644-62-1

Technical Data

AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
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Description

Afuresertib is a potent pan-AKT inhibitor that demonstrated synergy with bortezomib in preclinical models of multiple myeloma (MM).
 

Chemical Structure

011811 - Afuresertib | CAS 1047644-62-1

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