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Apaziquone

Catalog No: 16071104
CAS Number: 114560-48-4
Purity: 98% by HPLC 

Apaziquone, also known as EO9, EOquin, is a n indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. This agent displays activity towards both hypoxic solid tumors, which exhibits higher expression of cytochrome P450 reductase, and well-oxygenated malignant cells that overexpress the bioreductive enzyme NQO1 (NAD(P)H: quinone oxidoreductase). Apaziquone may selectively sensitize hypoxic tumor cells to radiocytotoxicity. Check for active clinical trials or closed clinical trials using this agent.  

For research use only. We do not sell to patients.

Chemical Information

NameApaziquone
Iupac Chemical Name5-(aziridin-1-yl)-3-(hydroxymethyl)-2-[(E)-3-hydroxyprop-1-enyl]-1-methylindole-4,7-dione 
SynonymsEO9; NSC 382459 
Molecular FormulaC15H16N2O4 
Molecular Weight288.3 
SmileN1(CC1)C=1C(C=2C(=C(N(C2C(C1)=O)C)\C=C\CO)CO)=O
InChiKeyMXPOCMVWFLDDLZ-NSCUHMNNSA-N
InChiInChI=1S/C15H16N2O4/c1-16-10(3-2-6-18)9(8-19)13-14(16)12(20)7-11(15(13)21)17-4-5-17/h2-3,7,18-19H,4-6,8H2,1H3/b3-2+
CAS Number114560-48-4
Related CAS

Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16071104 - Apaziquone | CAS 114560-48-4

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