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Apoptozole

Catalog No: 161014002
CAS Number: 1054543-47-3
Purity: 98% by HPLC 

Apoptosis Activator VII, Apoptozole is a cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 M). 

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Chemical Information

NameApoptozole
Molecular FormulaC33H24F6N3O3 
Molecular Weight625.6 
SmileCOc1ccc(cc1)c2c(n(c(n2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)Cc4ccc(cc4)C(=O)N)c5ccc(cc5)OC
InChiKeyZIMMTPFXOMAJTQ-UHFFFAOYSA-N
InChiInChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
CAS Number1054543-47-3
MDLMFCD19443178
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

161014002 - Apoptozole | CAS 1054543-47-3

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