Apremilast (CC-10004) is a potent and orally active PDE4 and TNF- inhibitor with IC50 of 74 nM and 77 nM, respectively.
For research use only. We do not sell to patients.
Name | Apremilast(CC-10004) |
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Iupac Chemical Name | Acetamide, N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- |
Synonyms | Apremilast;CC-10004 |
Molecular Formula | C22H24N2O7S |
Molecular Weight | 460.5 |
Smile | C(C)OC=1C=C(C=CC1OC)[C@@H](CS(=O)(=O)C)N1C(C2=CC=CC(=C2C1=O)NC(C)=O)=O |
InChiKey | IMOZEMNVLZVGJZ-QGZVFWFLSA-N |
InChi | InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1 |
CAS Number | 608141-41-9 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | off-white solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder 6 months-80ºCin solvent |
Solubility | 90mg/ml in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature. |
HS Code |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |