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Cobicistat(GS-9350) Catalog No : 51906

Chemical Information

Product NameCobicistat(GS-9350)
Iupac Chemical Name2,7,10,12-Tetraazatridecanoic acid, 12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3R,6R,9S)- 
SynonymsCobicistat;GS-9350;Tybost(trade name);GS9350;GS 9350 
Molecular FormulaC40H53N7O5S2 
Molecular Weight776.02 
SmileCN(C(N[C@H](C(N[C@H](CC[C@@H](NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1)CC1=CC=CC=C1)=O)CCN1CCOCC1)=O)CC=1N=C(SC1)C(C)C
InChiKeyZCIGNRJZKPOIKD-CQXVEOKZSA-N
InChiInChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1
Cas1004316-88-4

Technical Data

Appearanceoff-white solid 
Purity98% 
Solubility5mg/ml in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature. 
Quality control

Description

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

 

 

Chemical Structure

51906 - Cobicistat(GS-9350) | CAS 1004316-88-4

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