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Copanlisib Catalog No : 16070917

Chemical Information

Product NameCopanlisib
Iupac Chemical Name2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide 
SynonymsBAY 80-6946 
Molecular FormulaC23H28N8O4 
Molecular Weight480.52 
SmileNC1=NC=C(C=N1)C(=O)NC1=NC=2C(=C(C=CC2C=2N1CCN2)OCCCN2CCOCC2)OC
InChiKeyPZBCKZWLPGJMAO-UHFFFAOYSA-N
InChiInChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)
Cas1032568-63-0

Technical Data

AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
Quality control

Description

Copanlisib, also known as BAY 80-6946, is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. 

Chemical Structure

16070917 - Copanlisib | CAS 1032568-63-0

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