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Debio-1347

Catalog No: 16122928
CAS Number: 1265229-25-1
Purity: 98% 

Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. 

For research use only. We do not sell to patients.

Chemical Information

NameDebio-1347
Iupac Chemical NameDebio-1347 
SynonymsDebio 1347; Debio1347; CH5183284; CH 5183284; CH-5183284; FF284; FF-284; FF 284 
Molecular FormulaC20H16N6O 
Molecular Weight356.38 
SmileNC1=C(C=NN1C1=CC2=C(N=C(N2)C)C=C1)C(=O)C=1NC2=CC=CC=C2C1
InChiKeyBEMNJULZEQTDJY-UHFFFAOYSA-N
InChiInChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
CAS Number1265229-25-1
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122928 - Debio-1347 | CAS 1265229-25-1

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