Defactinib
Catalog No: 120111
CAS Number: 1073154-85-4
Purity: 98%
Defactinib is a potent FAK phosphorylation inhibitor; overcomes YB-1Cmediated paclitaxel resistance by an AKT-dependent pathway.
For research use only. We do not sell to patients.
Chemical Information
| Name | Defactinib |
|---|---|
| Iupac Chemical Name | N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide |
| Synonyms | VS-6063; VS6063; VS 6063; PF04554878; PF-04554878; PF 04554878 |
| Molecular Formula | C20H21F3N8O3S |
| Molecular Weight | 510.49 |
| Smile | CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F |
| InChiKey | FWLMVFUGMHIOAA-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30) |
| CAS Number | 1073154-85-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
