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Ertiprotafib

Catalog No: 16122942
CAS Number: 251303-04-5
Purity: 98% 

Ertiprotafib, also known as PTP-112, is a Protein Tyrosine Phosphatase 1B Inhibitor (PTP1B inhibitor). Ertiprotafib normalized the plasma glucose and insulin levels in diabetic animal models, and progressed to a phase II clinical trial. Ertiprotafib is potentially useful for the treatment of Non-Insulin Dependent Diabetes. Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms. Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta), with an IC(50) of 400nM. 

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Chemical Information

NameErtiprotafib
Iupac Chemical Name(2R)-2-(4-(9-bromo-2,3-dimethylnaphtho(2,3-b)thiophen-4-yl)-2,6-dimethylphenoxy)-3-phenylpropionic acid 
SynonymsPTP-112; PTP112; PTP 112 
Molecular FormulaC31H27BrO3S 
Molecular Weight559.52 
SmileBrC1=C2C=CC=CC2=C(C2=C1SC(=C2C)C)C2=CC(=C(O[C@@H](C(=O)O)CC1=CC=CC=C1)C(=C2)C)C
InChiKeyFONCZICQWCUXEB-RUZDIDTESA-N
InChiInChI=1S/C31H27BrO3S/c1-17-14-22(15-18(2)29(17)35-25(31(33)34)16-21-10-6-5-7-11-21)27-23-12-8-9-13-24(23)28(32)30-26(27)19(3)20(4)36-30/h5-15,25H,16H2,1-4H3,(H,33,34)/t25-/m1/s1
CAS Number251303-04-5
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Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122942 - Ertiprotafib | CAS 251303-04-5

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