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FF-10101 Catalog No : 181244

Chemical Information

Product NameFF-10101
Iupac Chemical Name(S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)pent-4-yn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide
SynonymsFF-10101; FF10101;FF 10101
Molecular FormulaC29H38N8O2
Molecular Weight530.66
SmileN#CC1=CC=C(NC2=NC(NCCC)=C(C#CCCCNC([C@H](C)N(C)C(/C=C/CN(C)C)=O)=O)C=N2)C=C1
InChiKeyHJFSVYUFOXAVAA-YUAYGMJFSA-N
InChiInChI=1S/C29H38N8O2/c1-6-17-31-27-24(21-33-29(35-27)34-25-15-13-23(20-30)14-16-25)11-8-7-9-18-32-28(39)22(2)37(5)26(38)12-10-19-36(3)4/h10,12-16,21-22H,6-7,9,17-19H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b12-10+/t22-/m0/s1
Cas1472797-69-5

Technical Data

AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
Quality control

Description

FF-10101 is a FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) inhibitor, with potential antineoplastic activity.Upon administration of FLT3 inhibitor FF-10101 succinate (FF-10101-01), FF-10101 irreversibly binds to and inhibits the activity of FLT3. This inhibits the proliferation of FLT3-expressing cancer cells. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. Check for active clinical trials using this agent. (NCI Thesaurus)

Chemical Structure

181244 - FF-10101 | CAS 1472797-69-5

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