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JPH203 ( KYT-0353 )

Catalog No: 6112701
CAS Number: 1037592-40-7
Purity: ≧98.0%

JPH203(also known as KYT-0353) is a potent and selective LAT1 selective ( L-type amino acid transporter 1) inhibitor. JPH203 can very potently inhibit l-leucine uptake. JPH203 inhibits YD-38 cell growth. JPH203 up-regulated the population of apoptotic YD-38 cells through the activation of apoptotic factors, including caspases and PARP. 

For research use only. We do not sell to patients.

Chemical Information

NameJPH203 ( KYT-0353 )
Iupac Chemical Name(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid 
SynonymsJPH203 ; JPH-203 ; JPH 203 ; KYT-0353 ; KYT 0353 ; KYT0353 
Molecular FormulaC23H19Cl2N3O4 
Molecular Weight471.1 
SmileO=C(O)[C@@H](N)CC1=CC(Cl)=C(OCC2=C(OC(C3=CC=CC=C3)=N4)C4=CC(N)=C2)C(Cl)=C1
InChiKeyXNRZJPQTMQZBCE-SFHVURJKSA-N
InChiInChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1
CAS Number1037592-40-7
Related CAS1597402-27-1 (2HCl) 1037592-40-7 (free base)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationlight-yellow to off-white solid 
Purity≧98.0%
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
SolubilitySoluble in DMSO, not in water 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1.    Choi DW, Kim DK, Kanai Y, Wempe MF, Endou H,, Kim JK. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607. doi: 10.4196/kjpp.2017.21.6.599. Epub 2017 Oct 30.

2.    Muto Y, Furihata T, Kaneko M, Higuchi K, Okunushi K, Morio H, Reien Y, Uesato M, Matsubara H, Anzai N., Different Response Profiles of Gastrointestinal Cancer Cells to an L-Type Amino Acid Transporter Inhibitor, JPH203. Anticancer Res. 2019 Jan;39(1):159-165. doi: 10.21873/anticanres.13092.

3.    Häfliger P, Graff J, Rubin M, Stooss A, Dettmer MS, Altmann KH, Gertsch J, Charles RP.,The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model. J Exp Clin Cancer Res. 2018 Sep 21;37(1):234. doi: 10.1186/s13046-018-0907-z.

4.    Yun DW, Lee SA, Park MG, Kim JS, Yu SK, Park MR, Kim SG, Oh JS, Kim CS, Kim HJ, Kim JS, Chun HS, Kanai Y, Endou H, Wempe MF, Kim DK., JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells. J Pharmacol Sci. 2014;124(2):208-17. Epub 2014 Feb 


Chemical Structure

6112701 - JPH203 ( KYT-0353 ) | CAS 1037592-40-7

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