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KC7F2

Catalog No: 16122827
CAS Number: 927822-86-4
Purity: 98% 

KC7F2 is a potent HIF-1 pathway inhibitor with potential anticancer activity. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 M. KC7F2 markedly inhibited HIF-mediated transcription in cells derived from different tumor types, including glioma, breast, and prostate cancers, and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevented the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), endothelin 1, and enolase 1. KC7F2 worked through the down-regulation of HIF-1alpha protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1alpha protein synthesis. 

For research use only. We do not sell to patients.

Chemical Information

NameKC7F2
Iupac Chemical NameN,N'-(disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide) 
SynonymsKC7F2 
Molecular FormulaC16H16Cl4N2O4S4 
Molecular Weight570.354 
SmileS(SCCNS(=O)(=O)C1=C(C=CC(=C1)Cl)Cl)CCNS(=O)(=O)C1=C(C=CC(=C1)Cl)Cl
InChiKeyREQLACDIZMLXIC-UHFFFAOYSA-N
InChiInChI=1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
CAS Number927822-86-4
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16122827 - KC7F2 | CAS 927822-86-4

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