KY-226
KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. KY-226 restores Akt (protein kinase B) phosphorylation and extracellular signal-regulated kinase (ERK) reduction in transient middle cerebral artery occlusion (tMCAO) damage. KY-226 protects BBB integrity by restoration of TJ proteins, an effect partly mediated by Akt/FoxO1 pathway activation.
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Chemical Information
| Name | KY-226 |
|---|---|
| Iupac Chemical Name | 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide |
| Synonyms | KY-226; KY 226; KY226; |
| Molecular Formula | C27H31NO3S2 |
| Molecular Weight | 481.669 |
| Smile | O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1 |
| InChiKey | MKXMABKUVSOEJF-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29) |
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Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Sun M, Shinoda Y, Fukunaga K. KY-226 Protects Blood-brain Barrier Function
Through the Akt/FoxO1 Signaling Pathway in Brain Ischemia. Neuroscience. 2019 Feb
10;399:89-102. doi: 10.1016/j.neuroscience.2018.12.024. Epub 2018 Dec 21. PubMed
PMID: 30579831.
2: Ito Y, Fukui M, Kanda M, Morishita K, Shoji Y, Kitao T, Hinoi E, Shirahase H.
Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor
KY-226 on experimental diabetes and obesity via enhancements in insulin and
leptin signaling in mice. J Pharmacol Sci. 2018 May;137(1):38-46. doi:
10.1016/j.jphs.2018.03.001. Epub 2018 Mar 6. PubMed PMID: 29731242.
3: Sun M, Izumi H, Shinoda Y, Fukunaga K. Neuroprotective effects of protein
tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice. Brain
Res. 2018 Sep 1;1694:1-12. doi: 10.1016/j.brainres.2018.04.029. Epub 2018 Apr 26.
PubMed PMID: 29705606.
Chemical Structure
