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LY3009120

Catalog No: 16123041
CAS Number: 1454682-72-4
Purity: 98% 

LY3009120, also known as DP-4978, is potent and selective pan-RAF inhibitor with potential anticancer activity. LY3009120 showed activities against BRaf or Ras mutant tumor cells . LY3009120 binds to ARaf, BRaf and CRaf isoforms with similar affinity in cells with activating mutations of BRaf or KRas. LY3009120 induces minimal paradoxical pathway activation in NRas or KRas mutant cells. LY3009120 inhibits MEK phosphorylation and cell proliferation in vitro, and exhibits anti-tumor activity in multiple xenograft models carrying mutations in BRaf, NRas or KRas. 

For research use only. We do not sell to patients.

Chemical Information

NameLY3009120
Iupac Chemical NameLY3009120 
SynonymsLY-3009120; LY 3009120; DP4978; DP 4978; DP-4978 
Molecular FormulaC23H29FN6O 
Molecular Weight424.52 
InChiKey
InChi
CAS Number1454682-72-4
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16123041 - LY3009120 | CAS 1454682-72-4

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