LY3039478 ( Crenigacestat )
Catalog No: 17021601
CAS Number: 1421438-81-4
Purity: ≧98.0%
LY3039478 ( Crenigacestat ), a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis.
For research use only. We do not sell to patients.
Chemical Information
| Name | LY3039478 ( Crenigacestat ) |
|---|---|
| Iupac Chemical Name | 4,4,4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-benzo[d]pyrido[2,3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide |
| Synonyms | LY3039478; LY 3039478; LY-3039478; Crenigacestat |
| Molecular Formula | C22H23F3N4O4 |
| Molecular Weight | 464.44 |
| Smile | O=C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CN=C3N(CCO)C1=O)=O)CCC(F)(F)F |
| InChiKey | YCBAQKQAINQRFW-UGSOOPFHSA-N |
| InChi | InChI=1S/C22H23F3N4O4/c1-13(27-17(31)8-9-22(23,24)25)20(32)28-18-15-6-3-2-5-14(15)16-7-4-10-26-19(16)29(11-12-30)21(18)33/h2-7,10,13,18,30H,8-9,11-12H2,1H3,(H,27,31)(H,28,32)/t13-,18-/m0/s1 |
| CAS Number | 1421438-81-4 |
| Related CAS | 1421438-81-4 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid to light yellow solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code | 2934200090 |
Coming soon.
| Targets | NOTCH1 inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
