MRTX1719
Catalog No: 262401
CAS Number: 2630904-45-7
Purity: ≧96.0%
MRTX1719 is a potent and selective binder to the PRMT5•MTA complex and selectively inhibits PRMT5 activity in MTAP-deleted cells compared to MTAP-wild-type cells. Daily oral administration of MRTX1719 to tumor xenograft-bearing mice demonstrated dose-dependent inhibition of PRMT5-dependent symmetric dimethylarginine protein modification in MTAP-deleted tumors that correlated with antitumor activity.
For research use only. We do not sell to patients.
Chemical Information
| Name | MRTX1719 |
|---|---|
| Iupac Chemical Name | 2-(4-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile |
| Synonyms | MRTX1719 ; MRTX 1719 ; MRTX-1719 ; |
| Molecular Formula | C23H18ClFN6O2 |
| Molecular Weight | 464.89 |
| Smile | N#CC1=[C@@]([C@@]2=C(C3=CC4=C(C(NN=C4CN)=O)C=C3)C=NN2C)C(F)=C(Cl)C=C1OC5CC5 |
| InChiKey | BZKIOORWZAXIBA-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H18ClFN6O2/c1-31-22(20-15(8-26)19(33-12-3-4-12)7-17(24)21(20)25)16(10-28-31)11-2-5-13-14(6-11)18(9-27)29-30-23(13)32/h2,5-7,10,12H,3-4,9,27H2,1H3,(H,30,32) |
| CAS Number | 2630904-45-7 |
| Related CAS | 2630904-45-7 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white to light-yellow solid |
|---|---|
| Purity | ≧96.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
