NS-1643
Catalog No: 17030715
CAS Number: 448895-37-2
Purity: 98%
NS-1643 is a Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 M). NS1643 increased both steady-state and tail current at all voltages tested. The EC(50) value for HERG channel activation was 10.5 microM. HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach.
For research use only. We do not sell to patients.
Chemical Information
| Name | NS-1643 |
|---|---|
| Iupac Chemical Name | 1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea |
| Synonyms | NS-1643; NS 1643; NS1643 |
| Molecular Formula | C15H10F6N2O3 |
| Molecular Weight | 380.2464 |
| Smile | OC1=C(C=C(C=C1)C(F)(F)F)NC(=O)NC1=C(C=CC(=C1)C(F)(F)F)O |
| InChiKey | NJFVQMRYJZHGME-UHFFFAOYSA-N |
| InChi | InChI=1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26) |
| CAS Number | 448895-37-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
