PD-173212
PD-173212 is a small molecule N-type calcium channel blocker. PD173212 fully reduced abdominal hypersensitivity to control values, highlighting the role of Cav2.2.
For research use only. We do not sell to patients.
Chemical Information
| Name | PD-173212 |
|---|---|
| Iupac Chemical Name | (S)-N-((S)-1-amino-3-(4-(benzyloxy)phenyl)-1-oxopropan-2-yl)-N-(tert-butyl)-2-((4-(tert-butyl)benzyl)(methyl)amino)-4-methylpentanamide |
| Synonyms | PD-173212; PD 173212; PD173212; |
| Molecular Formula | C38H53N3O3 |
| Molecular Weight | 599.85 |
| Smile | O=C(N)[C@H](CC1=CC=C(OCC2=CC=CC=C2)C=C1)N(C([C@H](CC(C)C)N(CC3=CC=C(C(C)(C)C)C=C3)C)=O)C(C)(C)C |
| InChiKey | WJAVQCPRFGVNSN-HEVIKAOCSA-N |
| InChi | InChI=1S/C38H53N3O3/c1-27(2)23-34(40(9)25-29-15-19-31(20-16-29)37(3,4)5)36(43)41(38(6,7)8)33(35(39)42)24-28-17-21-32(22-18-28)44-26-30-13-11-10-12-14-30/h10-22,27,33-34H,23-26H2,1-9H3,(H2,39,42)/t33-,34-/m0/s1 |
| CAS Number | 217171-01-2 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Hu LY, Ryder TR, Rafferty MF, Dooley DJ, Geer JJ, Lotarski SM, Miljanich GP, Millerman E, Rock DM, Stoehr SJ, Szoke BG, Taylor CP, Vartanian MG. Structure-activity relationship of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2151-6. PubMed PMID: 10465535.
2: Ryder TR, Hu LY, Rafferty MF, Millerman E, Szoke BG, Tarczy-Hornoch K. Multiple parallel synthesis of N,N-dialkyldipeptidylamines as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1813-8. PubMed PMID: 10406647.
Chemical Structure
