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PF-06463922 Catalog No : 51701

Chemical Information

Product NamePF-06463922
Iupac Chemical Name(10R)-7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile 
Molecular FormulaC21H19FN6O2 
Molecular Weight406.41 
SmileCC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C
InChiKeyIIXWYSCJSQVBQM-UHFFFAOYSA-N
InChiInChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)
Cas1454846-35-5

Technical Data

Appearanceoff-white solid 
Purity98% 
Solubility90mg/ml in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature. 
Quality control

Description

PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and Cros oncogene 1 (Ros1), with potential antineoplastic activity.  

Chemical Structure

51701 - PF-06463922 | CAS 1454846-35-5

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