Ribociclib HCl
Catalog No: 17011305
CAS Number: 1211443-80-9
Purity: 98%
Ribociclib hydrochloride is an potent and orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.
For research use only. We do not sell to patients.
Chemical Information
| Name | Ribociclib HCl |
|---|---|
| Iupac Chemical Name | 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride |
| Synonyms | Ribociclib hydrochloride; LEE011; LEE-011. LEE 011 |
| Molecular Formula | C23H31ClN8O |
| Molecular Weight | 471.006 |
| Smile | Cl.C1(CCCC1)N1C(=CC2=C1N=C(N=C2)NC2=NC=C(C=C2)N2CCNCC2)C(=O)N(C)C |
| InChiKey | JZRSIQPIKASMEV-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H30N8O.ClH/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1H |
| CAS Number | 1211443-80-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
