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SAG

Catalog No: 92802
CAS Number: 912545-86-9
Purity: 99.03%

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes  Cyclopamine action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins.

For research use only. We do not sell to patients.

Chemical Information

NameSAG
Iupac Chemical Name3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide 
SynonymsSAG
Molecular FormulaC28H28ClN3OS 
Molecular Weight490.06 
SmileO=C(C1=C(Cl)C2=CC=CC=C2S1)N([C@H]3CC[C@H](NC)CC3)CC4=CC=CC(C5=CC=NC=C5)=C4
InChiKeyVFSUUTYAEQOIMW-YHBQERECSA-N
InChiInChI=1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
CAS Number912545-86-9
Related CAS2095432-58-7 (HCl) 912545-86-9 (free base)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationlight yellow solid 
Purity99.03%
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
SolubilitySoluble in DMSO to 20 mM 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

92802 - SAG | CAS 912545-86-9

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