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SBI0206965

Catalog No: 71161
CAS Number: 1884220-36-3
Purity: 98% 

SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic. 

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For research use only. We do not sell to patients.

Chemical Information

NameSBI0206965
Iupac Chemical Name2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide 
SynonymsSBI-0206965; SBI 0206965; SBI0206965 
Molecular FormulaC21H21BrN4O5 
Molecular Weight489.33 
SmileBrC=1C(=NC(=NC1)NC1=CC(=C(C(=C1)OC)OC)OC)OC1=C(C(=O)NC)C=CC=C1
InChiKeyNEXGBSJERNQRSV-UHFFFAOYSA-N
InChiInChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
CAS Number1884220-36-3
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid to white solid
Purity98% 
Storage3 years -20ºCpowder 
Solubility10 mM in DMSO;
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

71161 - SBI0206965 | CAS 1884220-36-3

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