Welcome to Sun-shine chemical
+86-17702719238 sales@sun-shinechem.com

SCH-23390 maleate

Catalog No: 2071501
CAS Number: 87134-87-0
Purity: 98% Min.

SCH-23390 hydrochloride is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). SCH-23390 hydrochloride is also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). It blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.

For research use only. We do not sell to patients.

Chemical Information

NameSCH-23390 maleate
Iupac Chemical Name(R)-8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol maleate
SynonymsSCH-23390; SCH23390; SCH 23390; SCH-23390 maleate;
Molecular FormulaC21H22ClNO5
Molecular Weight403.859
SmileOC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1.O=C(O)/C=C\C(O)=O
InChiKeyFGHVSEXHEAUJBT-HFNHQGOYSA-N
InChi InChI=1S/C17H18ClNO.C4H4O4/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;5-3(6)1-2-4(7)8/h2-6,9-10,15,20H,7-8,11H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m1./s1
CAS Number87134-87-0
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-177 0271 9238   Email : sales@sun-shinechem.com
FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Dhir A, Kulkarni SK. Involvement of dopamine (DA)/serotonin (5-HT)/sigma (sigma) receptor modulation in mediating the antidepressant action of ropinirole hydrochloride, a D2/D3 dopamine receptor agonist. Brain Res Bull. 2007 Sep 14;74(1-3):58-65. PubMed PMID: 17683790.

2: Rao TS, Reid RT, Correa LD, Santori EM, Gardner MF, Sacaan AI, Lorrain D, Vernier JM. In vivo pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies. Brain Res. 2003 Oct 3;986(1-2):71-81. PubMed PMID: 12965231.

3: Fleckenstein AE, Pögün S, Carroll FI, Kuhar MJ. Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 [3 beta-(3p-chlorophenyl) tropan-2 beta-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride]. J Pharmacol Exp Ther. 1996 Oct;279(1):200-6. PubMed PMID: 8858994.

4: Cheetham SC, Kettle CJ, Martin KF, Heal DJ. D1 receptor binding in rat striatum: modification by various D1 and D2 antagonists, but not by sibutramine hydrochloride, antidepressants or treatments which enhance central dopaminergic function. J Neural Transm Gen Sect. 1995;102(1):35-46. PubMed PMID: 8785022.

5: Napoleone P, Cavallotti C, Ricci A, Amenta F. Dopexamine hydrochloride in the human kidney: localization, receptor binding and effect on 3'-5'-cyclic adenosine monophosphate generation. Nephron. 1993;65(3):385-91. PubMed PMID: 7904730.

6: Napoleone P, Ricci A, Ferrante F, Amenta F. Dopexamine hydrochloride in the human heart: receptor binding and effects on cAMP generation. Eur Heart J. 1992 Dec;13(12):1709-17. PubMed PMID: 1363232.

7: Paalzow GH. L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. J Pharmacol Exp Ther. 1992 Nov;263(2):470-9. PubMed PMID: 1432683.

8: Bass AS. Presynaptic effects of dopexamine hydrochloride in the canine kidney. Naunyn Schmiedebergs Arch Pharmacol. 1992 Jan;345(1):33-6. PubMed PMID: 1347154.

9: Amenta F, Ricci A, Napoleone P, Vyas SJ, Lokhandwala MF. Anatomical localization of the binding and functional characterization of responses to dopexamine hydrochloride in the rat mesenteric vasculature. Pharmacology. 1991;42(4):211-22. PubMed PMID: 1677201.

10: Vyas SJ, Apparsundaram S, Ricci A, Amenta F, Lokhandwala MF. Biochemical, autoradiographic and pharmacological evidence for the involvement of tubular DA-1 receptors in the natriuretic response to dopexamine hydrochloride. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jan;343(1):21-30. PubMed PMID: 1674360.

11: Bass AS. Contrasting effects of dopexamine hydrochloride on electrolyte excretion in canine kidney. J Pharmacol Exp Ther. 1990 May;253(2):798-802. PubMed PMID: 1971021.

12: Chintala MS, Lokhandwala MF, Jandhyala BS. Protective effects of dopexamine hydrochloride in renal failure after acute haemorrhage in anaesthetized dogs. J Auton Pharmacol. 1990;10 Suppl 1:s95-102. PubMed PMID: 1965897.

13: Smith GW, Hall JC, Farmer JB, Simpson WT. The cardiovascular actions of dopexamine hydrochloride, an agonist at dopamine receptors and beta 2-adrenoceptors in the dog. J Pharm Pharmacol. 1987 Aug;39(8):636-41. PubMed PMID: 2888855.


Chemical Structure

2071501 - SCH-23390 maleate | CAS 87134-87-0

Quick Order

Change