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TVB-3664

Catalog No: 2041503
CAS Number:
Purity: 98% Min.

TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression.

For research use only. We do not sell to patients.

Chemical Information

NameTVB-3664
Iupac Chemical Name4-(1-(5-(4-(methoxymethyl)-2-(trifluoromethyl)-1H-imidazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile
SynonymsTVB-3664; TVB 3664; TVB3664.
Molecular FormulaC25H23F3N4O2
Molecular Weight468.48
SmileCC1=C(C2=C(COC)N=C(C(F)(F)F)N2)C=C(C(N3CC(C4=CC=C(C#N)C=C4)C3)=O)C(C)=C1
InChiKeyYFEOVRCUSPPGFZ-UHFFFAOYSA-N
InChi InChI=1S/C25H23F3N4O2/c1-14-8-15(2)20(9-19(14)22-21(13-34-3)30-24(31-22)25(26,27)28)23(33)32-11-18(12-32)17-6-4-16(10-29)5-7-17/h4-9,18H,11-13H2,1-3H3,(H,30,31)
CAS Number
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationSolid powder
Purity98% Min.
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Heuer TS, Ventura R, Mordec K, Lai J, Fridlib M, Buckley D, Kemble G. FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression. EBioMedicine. 2017 Feb;16:51-62. doi: 10.1016/j.ebiom.2016.12.012. Epub 2016 Dec 24. PubMed PMID: 28159572.

Chemical Structure

2041503 - TVB-3664

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