TWS-119
Catalog No: 17030204
CAS Number: 601514-19-6
Purity: 98%
TWS-119 is a potent and selective inhibitor of glycogen synthase kinase-3 (IC50 = 30 nM). TWS119 could activate Wnt/-catenin pathway and up-regulate the expression of CD62L in a dose-dependent manner, but it decreased the expression of CD107a. Glycogen synthase kinase (GSK)-3, a constitutively active serine-threonine kinase, acts as a key regulator of major signaling pathways, including the Wnt, Hedgehog, and Notch pathways.
For research use only. We do not sell to patients.
Chemical Information
| Name | TWS-119 |
|---|---|
| Iupac Chemical Name | 3-((6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenol |
| Synonyms | TWS-119; TWS119; TWS 119 |
| Molecular Formula | C18H14N4O2 |
| Molecular Weight | 318.34 |
| Smile | NC=1C=C(C=CC1)C1=CC2=C(N=CN=C2OC=2C=C(C=CC2)O)N1 |
| InChiKey | VPVLEBIVXZSOMQ-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22) |
| CAS Number | 601514-19-6 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | off-white solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
