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VE-822 Catalog No : 51607

Chemical Information

Product NameVE-822
Iupac Chemical Name2-Pyrazinamine, 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]- 
SynonymsVE-822,VX-970;VE822;VE 822
Molecular FormulaC24H25N5O3S 
Molecular Weight463.55 
SmileCNCC1=CC=C(C=C1)C1=NOC(=C1)C=1C(=NC=C(N1)C1=CC=C(C=C1)S(=O)(=O)C(C)C)N
InChiKeyJZCWLJDSIRUGIN-UHFFFAOYSA-N
InChiInChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
Cas1232416-25-9

Technical Data

Appearanceyellow solid 
Purity98% 
Solubility5mg/ml in DMSO 
Storage3 years -20ºCpowder 
Quality control HNMR HPLC COA

Description

VE-822, an analogue of VE-821 with increased potency and selectivity against ATR, increased solubility and good pharmacokinetic properties was shown to potently radiosensitise pancreatic cancer cell lines in vitro.VE-822 was the first selective ATR inhibitor to enter clinical development, and is now known as VX-970. In a recent study, published by Vertex Pharmaceuticals, VX-970 (VE-822) was shown to markedly sensitise a panel of non-small cell lung cancer cell lines, but not normal cells, to multiple DNA damaging drugs, namely cisplatin, oxaliplatin, gemcitabine, etoposide and SN38, the active metabolite of irinotecan.

 

Chemical Structure

51607 - VE-822 | CAS 1232416-25-9

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