XL388
Catalog No: 161009016
CAS Number: 1251156-08-7
Purity: 98% by HPLC
XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.
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Chemical Information
| Name | XL388 |
|---|---|
| Iupac Chemical Name | (7-(6-aminopyridin-3-yl)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)(3-fluoro-2-methyl-4-(methylsulfonyl)phenyl)methanone |
| Synonyms | XL388; XL-388; XL 388. |
| Molecular Formula | C23H22FN3O4S |
| Molecular Weight | 455.5 |
| Smile | NC1=CC=C(C=N1)C=1C=CC2=C(CN(CCO2)C(=O)C2=C(C(=C(C=C2)S(=O)(=O)C)F)C)C1 |
| InChiKey | LNFBAYSBVQBKFR-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) |
| CAS Number | 1251156-08-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
