ZSTK474
Catalog No: 160926006
CAS Number: 475110-96-4
Purity: 98% by HPLC
Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3 by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth.
For research use only. We do not sell to patients.
Chemical Information
| Name | ZSTK474 |
|---|---|
| Iupac Chemical Name | 4,4'-(6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine |
| Synonyms | ZSTK474; ZSTK-474; ZSTK 474 |
| Molecular Formula | C19H21F2N7O2 |
| Molecular Weight | 417.41255 |
| Smile | FC(C1=NC2=C(N1C1=NC(=NC(=N1)N1CCOCC1)N1CCOCC1)C=CC=C2)F |
| InChiKey | HGVNLRPZOWWDKD-UHFFFAOYSA-N |
| InChi | InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2 |
| CAS Number | 475110-96-4 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
