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lumateperone(Tosylate) Catalog No : 17012102

Chemical Information

Product Namelumateperone(Tosylate)
Iupac Chemical Name1-(4-fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]butan-1-one toluenesulfonic acid 
SynonymsITI 007;ITI-007;ITI007;lumateperone Tosylate 
Molecular FormulaC₃₁H₃₆FN₃O₄S 
Molecular Weight565.7 
SmileO=C(C1=CC=C(F)C=C1)CCCN2CC[C@@](N3CCN(C)C4=C3C5=CC=C4)([H])[C@@]5([H])C2.CC6=CC=C(S(=O)(O)=O)C=C6
InChiKeyLHAPOGAFBLSJJQ-GUTACTQSSA-N
InChiInChI=1S/C24H28FN3O.C7H8O3S/c1-26-14-15-28-21-11-13-27(16-20(21)19-4-2-5-22(26)24(19)28)12-3-6-23(29)17-7-9-18(25)10-8-17;1-6-2-4-7(5-3-6)11(8,9)10/h2,4-5,7-10,20-21H,3,6,11-16H2,1H3;2-5H,1H3,(H,8,9,10)/t20-,21-;/m0./s1
Cas1187020-80-9

Technical Data

Appearanceoff-white solid 
Purity97% by HNMR /HPLC 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control HNMR

Description

Lumateperone (ITI-722/ITI-007) is a novel, first-in-class dual 5HT2A receptor antagonist/dopamine phosphoprotein modulator (DPPM) for schizophrenia. It is an orally available compound which combines potent 5HT2A receptor antagonism with cell-type-specific modulation of phosphoprotein pathways downstream of dopamine receptors. As of May 2015, Lumateperone is in phase III clinical trials for schizophrenia.

 

Chemical Structure

17012102 - lumateperone(Tosylate) | CAS 1187020-80-9

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