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SRT1720 编号 : 52007

化学信息

产品英文名称SRT1720
Iupac 化学名称N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride 
同义词SRT1720,SRT-1720,SRT 1720 
英文同义词SRT1720,SRT-1720,SRT 1720 
分子式C25H23N7OS.HCl 
分子量506.02 
SmileO=C(C1=NC2=CC=CC=C2N=C1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCNCC6)=N4.[H]Cl
InChiKeyDTGRRMPPXCRRIM-UHFFFAOYSA-N
InChiInChI=1S/C25H23N7OS.ClH/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31;/h1-8,13,15-16,26H,9-12,14H2,(H,29,33);1H
Cas1001645-58-4(HCl);925434-55-5(free base)

技术数据

外观yellow solid,being red exposed in air. 
纯度98% 
可溶性2mg/ml in DMSO 
存储3 years -20ºCpowder 
运输条件Shipped under ambient temperature 
质量控制

产品详情

SRT1720 is a selective SIRT1 activator with EC50 of 0.16 M, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720(SRT-1720) is an experimental drug that was studied by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. The compound has been studied in animals, but safety and efficacy in humans have not been established. 

结构

52007 - SRT1720 | CAS 1001645-58-4(HCl);925434-55-5(free base)

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