(+)-Apogossypol(Apogossypol; NSC736630) is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 M.
For research use only. We do not sell to patients.
Name | (+)-Apogossypol |
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Iupac Chemical Name | (+)-Apogossypol |
Synonyms | Apogossypol; NSC736630 |
Molecular Formula | C28H30O6 |
Molecular Weight | 462.53 |
Smile | Cc1cc2c(cc(c(c2C(C)C)O)O)c(c1c3c(cc4c(c3O)cc(c(c4C(C)C)O)O)C)O |
InChiKey | PBJKWGWHZVXBGU-UHFFFAOYSA-N |
InChi | InChI=1S/C28H30O6/c1-11(2)21-15-7-13(5)23(25(31)17(15)9-19(29)27(21)33)24-14(6)8-16-18(26(24)32)10-20(30)28(34)22(16)12(3)4/h7-12,29-34H,1-6H3 |
CAS Number | 66389-74-0 |
MDL | MFCD23160033 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | crystalline solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |