1V209
1V209, also known as TLR7 agonist T7, is a novel Toll-like receptor 7 (TLR7) agonist, eliciting the nonspecific antitumor responses and strengthening the specific humoral and cellular immune responses.
For research use only. We do not sell to patients.
Chemical Information
| Name | 1V209 |
|---|---|
| Iupac Chemical Name | 4-[[6-Amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-benzoic acid |
| Synonyms | TLR7 agonist T7; 1V209; 1V-209; 1V 209; |
| Molecular Formula | C16H17N5O5 |
| Molecular Weight | 359.34 |
| Smile | O=C(O)C1=CC=C(CN2C(NC3=C(N)N=C(OCCOC)N=C23)=O)C=C1 |
| InChiKey | ATISKRYGYNSRNP-UHFFFAOYSA-N |
| InChi | InChI=1S/C16H17N5O5/c1-25-6-7-26-15-19-12(17)11-13(20-15)21(16(24)18-11)8-9-2-4-10(5-3-9)14(22)23/h2-5H,6-8H2,1H3,(H,18,24)(H,22,23)(H2,17,19,20) |
| CAS Number | 1062444-54-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
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| Clinical study |
1: Zhang N, Jin G, Jin Z, Liu B, Peng B, Gao N, Hu Y, Tang L. [Combination of TLR7 agonist T7-ethacrynic acid conjugate with ROR1 has a stronger anti-breast cancer effect]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jul;32(7):876-80. Chinese. PubMed PMID: 27363264.
2: Wang XD, Gao NN, Diao YW, Liu Y, Gao D, Li W, Wan YY, Zhong JJ, Jin GY. Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects. World J Gastroenterol. 2015 Jul 14;21(26):8052-60. doi: 10.3748/wjg.v21.i26.8052. PubMed PMID: 26185376; PubMed Central PMCID: PMC4499347.
3: Lin G, Wang X, Yi W, Zhang C, Xu G, Zhu X, Cai Z, Liu Y, Diao Y, Lin MC, Jin G. A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma. J Transl Med. 2015 May 20;13:166. doi: 10.1186/s12967-015-0524-y. PubMed PMID: 25990580; PubMed Central PMCID: PMC4455914.
Chemical Structure
