2-MNG
2-MNG is an inhibitor for melanogenesis with an average IC50 of 49.5μM. 2-MNG alone significantly reduced immediate darkening and inhibited new melanin production when compared with vehicle, with higher performance at 1% than at 0.5%. 2-MNG at 0.5% in association with LHA and MSX showed significantly higher performance than 2-MNG 0.5% alone. 2-MNG at 0.5% and 1% showed significantly better performance than 4-n-BR.
For research use only. We do not sell to patients.
Chemical Information
| Name | 2-MNG |
|---|---|
| Iupac Chemical Name | (2-thioxo-1,2-dihydropyridine-3-carbonyl)glycine |
| Synonyms | 2-MNG; 2 MNG; 2MNG; 2-Mercaptonicotinoyl glycine |
| Molecular Formula | C8H8N2O3S |
| Molecular Weight | 212.23 |
| Smile | O=C(O)CNC(C1=CC=CNC1=S)=O |
| InChiKey | LJJOEVWTSMQPDV-UHFFFAOYSA-N |
| InChi | InChI=1S/C8H8N2O3S/c11-6(12)4-10-7(13)5-2-1-3-9-8(5)14/h1-3H,4H2,(H,9,14)(H,10,13)(H,11,12) |
| CAS Number | 2101538-28-5 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Sextius P, Warrick E, Prévot-Guéguiniat A, Lereaux G, Boirre F, Baux L, Hassine SB, Qiu J, Huang X, Xu J, Grégoire S, Ito S, Wakamatsu K, Marat X. 2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity. Pigment Cell Melanoma Res. 2024 Jul;37(4):462-479. doi: 10.1111/pcmr.13168. Epub 2024 Apr 1. PMID: 38560773.
2: Dibdiakova K, Majercikova Z, Galanda T, Richterova R, Kolarovszki B, Racay P, Hatok J. Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors. Int J Mol Sci. 2024 Mar 1;25(5):2858. doi: 10.3390/ijms25052858. PMID: 38474106; PMCID: PMC10932124.
3: Muller B, Flament F, Jouni H, Sextius P, Tachon R, Wang Y, Wang H, Qiu H, Qiu J, Amar D, Delaunay C, Jablonski NG, Passeron T. A Bayesian network meta- analysis of 14 molecules inhibiting UV daylight-induced pigmentation. J Eur Acad Dermatol Venereol. 2024 Aug;38(8):1566-1574. doi: 10.1111/jdv.19910. Epub 2024 Mar 3. PMID: 38433524.
4: de Dormael R, Sextius P, Bourokba N, Mainguene E, Tachon R, Gaurav K, Jouni H, Bastien P, Diridollou S. 2-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study. J Cosmet Dermatol. 2024 May;23(5):1745-1752. doi: 10.1111/jocd.16200. Epub 2024 Feb 19. PMID: 38372022.
Chemical Structure
