4EGI-1
Catalog No: 102608
CAS Number: 315706-13-9
Purity: 98%
4EGI-1 is a cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 M) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation.
For research use only. We do not sell to patients.
Chemical Information
| Name | 4EGI-1 |
|---|---|
| Iupac Chemical Name | 2-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid |
| Synonyms | eIF4E/eIF4G Interaction Inhibitor |
| Molecular Formula | C18H16Cl2N4O4S |
| Molecular Weight | 455.315 |
| Smile | C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-] |
| InChiKey | KFRKRECSIYXARE-UHFFFAOYSA-N |
| InChi | InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26) |
| CAS Number | 315706-13-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
