ACT-389949 (ACT389949)
Catalog No: 20211801
CAS Number: 1258417-54-7
Purity: 98% Min.
ACT-389949 is a potent and selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes.
For research use only. We do not sell to patients.
Chemical Information
| Name | ACT-389949 (ACT389949) |
|---|---|
| Iupac Chemical Name | 2-methyl-5-m-tolyloxazol-4-carboxylic acid {2-[4-(1,1-difluoroethyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl}amide |
| Synonyms | ACT389949 |
| Molecular Formula | C20H18F2N6O3 |
| Molecular Weight | 428.39 |
| Smile | O=C(NC1=NN(N=C1)CC2=NC(C(F)(C)F)=CO2)C3=C(OC(C)=N3)C4=CC=CC(C)=C4 |
| InChiKey | PBTWPEDVIMHJEO-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H18F2N6O3/c1-11-5-4-6-13(7-11)18-17(24-12(2)31-18)19(29)26-15-8-23-28(27-15)9-16-25-14(10-30-16)20(3,21)22/h4-8,10H,9H2,1-3H3,(H,26,27,29) |
| CAS Number | 1258417-54-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Stalder AK, Lott D, Strasser DS, et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017;83(3):476‐486. doi:10.1111/bcp.13149
2: Lind S, Sundqvist M, Holmdahl R, Dahlgren C, Forsman H, Olofsson P. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019;166:163‐173. doi:10.1016/j.bcp.2019.04.030
Chemical Structure
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