AF-710B
AF-710B is an agonist of sigma and M1 muscarinic receptors; AF710B is an enantiomer of AF710.
For research use only. We do not sell to patients.
Chemical Information
| Name | AF-710B |
|---|---|
| Iupac Chemical Name | 1-Propanone, 1-(2,8-dimethyl-1-thia-3,8-diazaspiro(4.5)dec-3-yl)-3-(1H-indol-3-yl) |
| Synonyms | AF-710B; AF 710B; AF710B |
| Molecular Formula | C20H27N3OS |
| Molecular Weight | 357.51 |
| Smile | O=C(N1C(C)SC2(CCN(C)CC2)C1)CCC3=CNC4=C3C=CC=C4 |
| InChiKey | XWMHYQATSBWUNT-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H27N3OS/c1-15-23(14-20(25-15)9-11-22(2)12-10-20)19(24)8-7-16-13-21-18-6-4-3-5-17(16)18/h3-6,13,15,21H,7-12,14H2,1-2H3 |
| CAS Number | 1235733-73-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Hall H, Iulita MF, Gubert P, Flores Aguilar L, Ducatenzeiler A, Fisher A, Cuello AC. AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease. Alzheimers Dement. 2017 Dec 29. pii: S1552-5260(17)33851-7. doi: 10.1016/j.jalz.2017.11.009. [Epub ahead of print] PubMed PMID: 29291374.
2: Fisher A, Bezprozvanny I, Wu L, Ryskamp DA, Bar-Ner N, Natan N, Brandeis R, Elkon H, Nahum V, Gershonov E, LaFerla FM, Medeiros R. AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease. Neurodegener Dis. 2016;16(1-2):95-110. PubMed PMID: 26606130; PubMed Central PMCID: PMC4803577.
Chemical Structure
