Treatment with this PI3K inhibitor enhanced myelination and axon number in the spinal cord of EAE mice. PI3K contributes to development of autoimmune CNS inflammation and that PI3K blockade may provide a great potential for treating patients with MS.
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Name | AS-604850 |
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Iupac Chemical Name | (Z)-5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methylene)thiazolidine-2,4-dione |
Synonyms | AS604850; AS 604850; AS-604850. |
Molecular Formula | C11H5F2NO4S |
Molecular Weight | 285.22 |
Smile | FC1(OC2=C(O1)C=CC(=C2)\C=C/2\C(NC(S2)=O)=O)F |
InChiKey | SRLVNYDXMUGOFI-YWEYNIOJSA-N |
InChi | InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4- |
CAS Number | 648449-76-7 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | Solid powder |
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Purity | 98% by HPLC |
Storage | -20 ºC for 3 years |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
Targets | |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |