Orally administration of AS605240 significantly prevented lung inflammation and reduced collagen deposition. AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. AS605240 may be a useful in treating inflammation diseases. AS605240 may represent a promising novel agent for the future therapy of pulmonary fibrosis.
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Name | AS-605240 |
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Iupac Chemical Name | (E)-5-(quinoxalin-6-ylmethylene)thiazolidine-2,4-dione |
Synonyms | AS 605240; AS605240; AS-605240. |
Molecular Formula | C12H7N3O2S |
Molecular Weight | 257.27 |
Smile | N1=CC=NC2=CC(=CC=C12)\C=C\1/C(NC(S1)=O)=O |
InChiKey | SQWZFLMPDUSYGV-UXBLZVDNSA-N |
InChi | InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6+ |
CAS Number | 648450-29-7 |
Related CAS |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | Solid powder |
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Purity | 98% by HPLC |
Storage | -20 ºC for 3 years |
Solubility | Soluble in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
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Cell study | |
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Clinical study |