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AT-007

Catalog No: 25071
CAS Number: 2170729-29-8
Purity: 98% Min.

AT-007 is an orally active central nervous system (CNS) penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM

For research use only. We do not sell to patients.

Chemical Information

NameAT-007
Iupac Chemical Name 2-(4-oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid
SynonymsAT-007; AT 007; AT007; Govorestat
Molecular FormulaC17H10F3N3O3S2
Molecular Weight425.40
SmileO=C(O)CC(C1=CSC=C12)=NN(CC3=NC4=CC(C(F)(F)F)=CC=C4S3)C2=O
InChiKeyORQGHAJIWGGFJK-UHFFFAOYSA-N
InChiInChI=1S/C17H10F3N3O3S2/c18-17(19,20)8-1-2-13-12(3-8)21-14(28-13)5-23-16(26)10-7-27-6-9(10)11(22-23)4-15(24)25/h1-3,6-7H,4-5H2,(H,24,25)
CAS Number2170729-29-8
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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FormulationOff-white solid
Purity98% Min.
StorageDry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

1: Zhu Y, Lobato AG, Rebelo AP, Canic T, Ortiz-Vega N, Tao X, Syed S, Yanick C,
Saporta M, Shy M, Perfetti R, Shendelman S, Züchner S, Zhai RG. Sorbitol
reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration
in sorbitol dehydrogenase deficiency. JCI Insight. 2023 May 22;8(10):e164954.
doi: 10.1172/jci.insight.164954. PMID: 37014713; PMCID: PMC10322690.

2: Perfetti R, Bailey E, Wang S, Mills R, Mohanlal R, Shendelman S. Safety,
Pharmacokinetics, and Pharmacodynamics of the New Aldose Reductase Inhibitor
Govorestat (AT-007) After a Single and Multiple Doses in Participants in a Phase
1/2 Study. J Clin Pharmacol. 2024 Nov;64(11):1397-1406. doi: 10.1002/jcph.2495.
Epub 2024 Jul 10. PMID: 38988185.

3: Bailey E, Phan H, Ahmad A, Thomas J, Ames EG, Pritchard AB, Quinonez SC, Wang
S, Dayley C, Salt A, Pick C, Durrant A, Johnson S, Nicodemus-Johnson J, Dickson
SP, Perfetti R, Hendrix SB, Shendelman S. Results of the ACTION-Galactosemia
Kids Study to Evaluate the Effects of Govorestat in Pediatric Patients with
Classic Galactosemia. J Clin Pharmacol. 2024 Nov 21. doi: 10.1002/jcph.6170.
Epub ahead of print. PMID: 39569553.

4: Randall JA, Sutter C, Wang S, Bailey E, Raither L, Perfetti R, Shendelman S,
Burbridge C. Qualitative interviews with adults with Classic Galactosemia and
their caregivers: disease burden and challenges with daily living. Orphanet J
Rare Dis. 2022 Mar 28;17(1):138. doi: 10.1186/s13023-022-02287-9. PMID:
35346295; PMCID: PMC8959560.

Chemical Structure

25071 - AT-007 | CAS 2170729-29-8

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