Barasertib (AZD1152-HQPA) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM, ~3700 fold more selective for Aurora B over Aurora A. Phase 1.
For research use only. We do not sell to patients.
Name | AZD1152-HQPA |
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Iupac Chemical Name | 2-(5-(7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-ylamino)-1H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide |
Synonyms | AZD1152-HQPA |
Molecular Formula | C26H30FN7O3 |
Molecular Weight | 507.56 |
Smile | C(C)N(CCCOC1=CC=C2C(=NC=NC2=C1)NC1=CC(=NN1)CC(=O)NC1=CC(=CC=C1)F)CCO |
InChiKey | QYZOGCMHVIGURT-UHFFFAOYSA-N |
InChi | InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) |
CAS Number | 722544-51-6 |
Related CAS |
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Formulation | off-white solid |
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Purity | 98% |
Storage | 3 years -20ºCpowder |
Solubility | 5mg/ml in DMSO |
Handling | |
Shipping Condition | Shipped under ambient temperature |
HS Code |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |